Clinical Challenges in Regenerative Endodontic Therapy: A Review
Keywords:
Disinfection, Immature teeth, Regenerative endodontic therapy, Scaffolds, Stem cellsAbstract
Regenerative endodontic therapy (RET) has drawn a great deal of interest and is widely recognized because it preserves the function and endurance of teeth. Although it is routinely performed on immature teeth with periapical disease, the treatment outcomes remain unpredictable. Instead of producing fibrous connective tissue and amorphous mineral deposits, pulp-dentin regeneration should be the real benchmark of RET. Still, we have not yet achieved the benchmark of full innervation and vascularization of the generated tissue in the root canal. The main challenges faced with the current clinical protocol of RET are the complete disinfection of root canal space and enhancing pulplike tissue regeneration. This article will address the key challenges and strategies that focus on realizing the goal of regenerative endodontic therapy
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